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The Hilbert transform is widely used in biomedical signal processing and requires efficient implementation. We propose the implementation of the discrete Hilbert transform based on emerging memristor devices. It uses two matrix multiplication layers using weights programmed in the memristor array and a linear Hadamard product calculation layer mappable to CMOS. The functionality was tested on a dataset of optical cardiac signals from the human heart. The results show negligible <1% angle error between the proposed implementation and the MATLAB function. It also has robustness to non-idealities. This proposed solution can be applied to bio-signal processing at the edge. 

Artificial intelligence algorithms are being adopted to analyze medical data, promising faster interpretation to support doctors’ diagnostics. The next frontier is to bring these powerful algorithms to implantable medical devices. Herein, a closed‐loop solution is proposed, where a cellular neural network is used to detect abnormal wavefronts and wavebrakes in cardiac signals recorded in human tissue is trained to achieve >96% accuracy, >92% precision, >99% specificity, and >93% sensitivity, when floating point precision weights are assumed. Unfortunately, the current hardware technologies for floating point precision are too bulky or energy intensive for compact standalone applications in medical implants. Emerging device technologies, such as memristors, can provide the compact and energy‐efficient hardware fabric to support these efforts and can be reliably embedded with existing sensor and actuator platforms in implantable devices. A distributed design that considers the hardware limitations in terms of overhead and limited bit precision is also discussed. The proposed distributed solution can be easily adapted to other medical technologies that require compact and efficient computing, like wearable devices and lab‐on‐chip platforms.